A Recombinant Measles Vaccine with Enhanced Resistance to Passive Immunity
نویسندگان
چکیده
منابع مشابه
A Recombinant Measles Vaccine with Enhanced Resistance to Passive Immunity
Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this concise communication, we show that a measles virus (MV) with enhanced hemagg...
متن کاملPrimary resistance phenomena to oncolytic measles vaccine viruses.
Measles vaccine virus (MeV) has been shown to possess profound oncolytic capabilities. However, tumor cell resistance to MeV may endanger broad clinical success. Here, this hypothesis is underlined by our analysis of the NCI-60 tumor cell panel infected with a suicide gene-armed MeV vector (MeV-SCD). Quantification of the MeV-SCD-induced oncolytic effect exhibited a 50% rate of NCI-60 solid tum...
متن کاملPassive hemagglutination test for measles immunity and serodiagnosis.
A passive hemagglutination (PHA) test for measles was evaluated in comparison with hemagglutination inhibition (HI) and neutralization (NT) tests. The PHA test determines exclusively the level of antibody directed to the hemagglutinin protein of measles virus. The ratio of PHA to HI titer was 1 to 32 (geometric mean, 6.5) for the first 5 weeks of infection but declined to near unity thereafter....
متن کاملEnhanced Passive Immunity to Streptococcus Infection in Rabbits
The experimental work herein reported tends to justify our hypothesis recently expressed, that the common failure of antibacterial serums to combat active infections when passively transferred to a normal animal, is due not so much to a lack of suitable or sufficient antibodies as to absence of cell preparation or mobilization in the recipient. In the case of experimental streptococcus empyema ...
متن کاملEffects of measles vaccine on humoral and cellular immunity
• Vol 10 • August-September 2008 640 Measles is still a significant cause of morbidity and mortality in children in the Middle East. This region has many hard-to-reach populations, causing difficulties in the provision of adequate immunization coverage. There has been concern that measles vaccine may produce transient immunosuppression in malnourished children and thereby increase their risk fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2017
ISSN: 1999-4915
DOI: 10.3390/v9100265